Karuk have lived in the Klamath-Siskiyou Mountains in the mid-Klamath River region of northern California beyond documented history, and now face severe climate change impacts to their territory and way of life. The Karuk Climate Adaptation Plan details climate impacts and adaptation strategies for the Karuk tribe and culture, local species and habitats, human health, critical infrastructure, tribal programs, tribal sovereignty and management authority. The climate adaptations evaluated have combined western science and Karuk traditional knowledge, and are recommended based on 22 focal species cultural indicators “for human responsibilities and necessary human actions” across seven habitat management zones.